Pathogenic Roles of Cardiac Fibroblasts in Pediatric Dilated Cardiomyopathy.

ABSTRACT: Background Dilated cardiomyopathy (DCM) is a major cause of heart failure in children. Despite intensive genetic analyses, pathogenic gene variants have not been identified in most patients with DCM, which suggests that cardiomyocytes are not solely responsible for DCM. Cardiac fibroblasts (CFs) are the most abundant cell type in the heart. They have several roles in maintaining cardiac function; however, the pathological role of CFs in DCM remains unknown. Methods and Results Four primary cultured CF cell lines were established from pediatric patients with DCM and compared with 3 CF lines from healthy controls. There were no significant differences in cellular proliferation, adhesion, migration, apoptosis, or myofibroblast activation between DCM CFs compared with healthy CFs. Atomic force

SUBMITTER: Tsuru H 

PROVIDER: S-EPMC10356057 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature