Discrimination Between Pre- and Postcapillary Pulmonary Hypertension Using Platelet RNA.

ABSTRACT: Background Appropriate treatment of pulmonary hypertension (PH) is critically dependent on accurate discrimination between pre- and postcapillary PH. However, clinical discrimination is challenging and frequently requires a right heart catheterization. Existing risk scores to detect postcapillary PH have suboptimal discriminatory strength. We have previously shown that platelet-derived RNA profiles may have diagnostic value for PH detection. Here, we hypothesize that platelet-derived RNAs can be employed to select unique biomarker panels for the discrimination between pre- and postcapillary PH. Methods and Results Blood platelet RNA from whole blood was isolated and sequenced from 50 patients with precapillary PH (with different PH subtypes) as well as 50 patients with postcapillary PH. RN

SUBMITTER: Arkani M 

PROVIDER: S-EPMC10356096 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature