Analysis of the cervical microbiome in women from the German national cervical cancer screening program.

ABSTRACT:

Purpose

Cervical cancer (CC) is caused by a persistent high-risk human papillomavirus (hrHPV) infection. The cervico-vaginal microbiome may influence the development of (pre)cancer lesions. Aim of the study was (i) to evaluate the new CC screening program in Germany for the detection of high-grade CC precursor lesions, and (ii) to elucidate the role of the cervico-vaginal microbiome and its potential impact on cervical dysplasia.

Methods

The microbiome of 310 patients referred to colposcopy was determined by amplicon sequencing and correlated with clinicopathological parameters.

Results

Most patients were referred for colposcopy due to a positive hrHPV result in two consecutive years combined with a normal PAP smear. In 2.1% of these cases, a CIN III lesion was detect

SUBMITTER: Condic M 

PROVIDER: S-EPMC10356625 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature