Chemical screening links disulfiram with cardiac protection after ischemic injury.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC10356704 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
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Chemical screening links disulfiram with cardiac protection after ischemic injury.
Chen Yuanyuan Y Du Jianyong J Zheng Lixia L Wang Zihao Z Zhang Zongwang Z Wu Zhengyuan Z Zhu Xiaojun X Xiong Jing-Wei JW
Cell regeneration (London, England) 20230719 1
Ischemia-reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are incompletely understood and effective pharmacological interventions are limited. Here, we report the identification and characterization of the FDA-approved drug disulfiram (DSF) as a cardioprotective compound. By applying high-throughput chemical screening, we found that DSF decreased H<sub>2</sub>O<sub>2</sub>-induced cardiomyocyte death by inhibiti ...[more]
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