Potential mechanisms linking high-volume exercise with coronary artery calcification.

ABSTRACT: Recent studies have found an association between high volumes of physical activity and increased levels of coronary artery calcification (CAC) among older male endurance athletes, yet the underlying mechanisms have remained largely elusive. Potential mechanisms include greater exposure to inflammatory cytokines, reactive oxygen species and oxidised low-density lipoproteins, as acute strenuous physical activity has been found to enhance their systemic release. Other possibilities include post-exercise elevations in circulating parathyroid hormone, which can modify the amount and morphology of calcific plaque, and long-term exposure to non-laminar blood flow within the coronary arteries during vigorous physical activity, particularly in individuals with pre-existing atherosclerosis. Further,

SUBMITTER: Zambrano A 

PROVIDER: S-EPMC10356745 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature