Ontology highlight
ABSTRACT:
SUBMITTER: Erazo-Oliveras A
PROVIDER: S-EPMC10356786 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Erazo-Oliveras Alfredo A Muñoz-Vega Mónica M Mlih Mohamed M Thiriveedi Venkataramana V Salinas Michael L ML Rivera-Rodríguez Jaileen M JM Kim Eunjoo E Wright Rachel C RC Wang Xiaoli X Landrock Kerstin K KK Goldsby Jennifer S JS Mullens Destiny A DA Roper Jatin J Karpac Jason J Chapkin Robert S RS
Nature communications 20230719 1
Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that Wnt signaling originates from highly dynamic nano-assemblies at the plasma membrane. However, little is known regarding the role of oncogenic APC in reshaping Wnt nanodomains. This is noteworthy, because oncogenic APC does not act autonomously and requires activation of Wnt effectors upstream of APC to drive aberrant Wnt signaling. Here, we demonstrate the role of on ...[more]