Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales.

ABSTRACT: Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limited evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months). At long timescales, memoranda may be encountered in multiple temporal contexts, potentially creating interference. Here, using 7T fMRI, we measured CA1 and entorhinal activity patterns as human participants viewed thousands of natural scene images distributed, and repeated, across many months. We show that memory for an image's original temporal context was predicted by the degree to which CA1/entorhinal activity patterns from the first encounter with an image were re-expressed during re-encounters occurring minutes to months later. Critically, t

SUBMITTER: Zou F 

PROVIDER: S-EPMC10356845 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature