Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines.

ABSTRACT:

Purpose

A wide therapeutic repertoire has become available to oncologists including radio- and chemotherapy, small molecules and monoclonal antibodies. However, drug efficacy can be limited by genetic heterogeneity. Here, we designed a webtool that facilitates the data analysis of the in vitro drug sensitivity data on 265 approved compounds from the GDSC database in association with a plethora of genetic changes documented for 1001 cell lines in the CCLE data.

Methods

The webtool computes odds ratios of drug resistance for a queried set of genetic alterations. It provides results on the efficacy of single compounds or groups of compounds assigned to cellular signaling pathways. Webtool availability: https://tools.hornlab.org/GDSC/ .

Results

We first replicated establi

SUBMITTER: Boeschen M 

PROVIDER: S-EPMC10356876 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature