IKK2/NFkB signaling controls lung resident CD8⁺ T cell memory during influenza infection.

ABSTRACT: CD8⁺ T cell tissue resident memory (T_RM) cells are especially suited to control pathogen spread at mucosal sites. However, their maintenance in lung is short-lived. TCR-dependent NFkB signaling is crucial for T cell memory but how and when NFkB signaling modulates tissue resident and circulating T cell memory during the immune response is unknown. Here, we find that enhancing NFkB signaling in T cells once memory to influenza is established, increases pro-survival Bcl-2 and CD122 levels thus boosting lung CD8⁺ T_RM maintenance. By contrast, enhancing NFkB signals during the contraction phase of the response leads to a defect in CD8⁺ T_RM differentiation without impairing recirculating memory subsets. Specifically, inducible ac

SUBMITTER: Pritzl CJ 

PROVIDER: S-EPMC10356942 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature