Prognostic value and chemotherapy response prediction of a proliferation essential gene signature in colon cancer.

ABSTRACT:

Background

Colon cancer is a common malignant tumor in the digestive tract. Exploring new treatment targets is of great significance for improving the survival rate of colon cancer patients. The present study mainly analyzes the impact of proliferation essential genes (PLEGs) on the prognosis and chemotherapy response of colon cancer patients, as well as identifying the expression and cellular functions of important PLEG.

Methods

The DepMap database was utilized for identification of PLEG in colon cancer cells. Through DEGs screening, WGCNA, univariate cox regression survival analysis, and LASSO, a PLEG signature (PLEGs) model was constructed. The impact of PLEGs on the prognosis of colon cancer patients and their response to chemotherapy was further analyzed. Finally, we co

SUBMITTER: Liu J 

PROVIDER: S-EPMC10357000 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature