Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.

ABSTRACT: Spatial organization within an organ is essential and needs to be maintained during development. This is largely implemented via compartment boundaries that serve as barriers between distinct cell types. Biased accumulation of junctional non-muscle Myosin II along the interface between differently fated groups of cells contributes to boundary integrity and maintains its shape via increased tension. Here, using the Drosophila wing imaginal disc, we tested whether interfacial tension driven by accumulation of Myosin is responsible for the elimination of aberrantly specified cells that would otherwise compromise compartment organization. To this end, we genetically reduced Myosin II levels in three different patterns: in both wild-type and misspecified cells, only in misspecified cells, and s

SUBMITTER: Klipa O 

PROVIDER: S-EPMC10357031 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature