Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.

ABSTRACT: The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration suggest that cdon and boc may play additional functions in regulating directed cell movements. We use newly generated and existing mutants to investigate a role for cdon and boc in zebrafish neural crest cell migration. We find that single mutant embryos exhibit normal neural crest phenotypes, but that neural crest migration is strikingly disrupted in double cdon;boc mutant embryos. We further show that this migration phenotype is associated with defects in the differentiation of slow-twitch muscle cells, and the loss of a Col1a1a-containing extracellular matrix, suggesting that neur

SUBMITTER: Lencer E 

PROVIDER: S-EPMC10357035 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature