Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Alzheimer's disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor.

Objective

To investigate the association between APOE4 and BCHE-K as a risk factor for AD.

Methods

We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.

Results

Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the me

SUBMITTER: Ratis RC 

PROVIDER: S-EPMC10357125 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature