Neurofilament Light Protein Predicts Disease Progression in Idiopathic REM Sleep Behavior Disorder.

ABSTRACT:

Background

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is increasingly recognized as a manifestation preceding the α-synucleinopathies like Parkinson's disease (PD). Neurofilament light chain (NfL) have been reported to be higher in synucleinopathies as a sign of neurodegeneration.

Objective

To evaluate whether plasma NfL is valuable in reflecting cognitive and motor status in iRBD and PD with a premorbid history of RBD (PDRBD), and predicting disease progression in iRBD.

Methods

Thirty-one patients with iRBD, 30 with PDRBD, and 18 healthy controls were included in the cross-sectional and prospective study. Another cohort from the Parkinson's Progression Markers Initiative (PPMI) dataset was enrolled for verification analysis. All patients received ev

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10357151 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature