Extracellular Tau Oligomers Damage the Axon Initial Segment.

ABSTRACT:

Background

In Alzheimer's disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating polarity and functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from axonal proteins and initiates action potentials. Toxic tau species, including extracellular oligomers (xcTauOs), spread tau pathology from neuron to neuron by a prion-like process, but few other cell biological effects of xcTauOs have been described.

Objective

Test the hypothesis that AIS structure is sensitive to xcTauOs.

Methods

Cultured wild type (WT) and tau knockout (KO) mouse cortical neurons were exposed to xcTauOs, and quantitative western blotting and immunofluorescence microscopy with anti-TRIM46 monitored effects on

SUBMITTER: Best MN 

PROVIDER: S-EPMC10357156 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature