Longitudinal Effects of Herpesviruses on Multiple Cognitive Outcomes in Healthy Elderly Adults.

ABSTRACT:

Background

Herpesviruses have been proposed to be involved in Alzheimer's disease development as potentially modifiable pathology triggers.

Objective

To investigate associations of serum antibodies for herpes simplex virus (HSV)-1 and cytomegalovirus (CMV) and anti-herpesvirus treatment with cognitive outcomes in relation to interactions with APOE ɛ4.

Methods

The study included 849 participants in the population-based Prospective Investigation of the Vasculature in Uppsala Seniors study. Cognitive performance at the ages of 75 and 80 years was assessed using the Mini-Mental State Examination (MMSE), trail-making test (TMT) A and B, and 7-minute screening test (7MS).

Results

Anti- HSV-1 IgG positivity was associated cross-sectionally with worse performance on th

SUBMITTER: Weidung B 

PROVIDER: S-EPMC10357165 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature