Altered Anterior Insular Metabolic Connectivity in Asymptomatic MAPT P301L Carriers.

ABSTRACT:

Background

The insula is the predominant brain region impaired in behavioral variant frontotemporal dementia (bvFTD). However, structural and functional changes in the sub-insula in the asymptomatic stage of bvFTD are unknown.

Objective

To describe structural and functional changes in insula subregions in asymptomatic carriers of the P301L mutation of the microtubule-associated protein tau (MAPT) gene and patients with bvFTD.

Methods

Six asymptomatic MAPT P301L mutation carriers and 12 MAPT negative control subjects of the same pedigree were enrolled, along with 30 patients with a clinical diagnosis of bvFTD and 30 matched controls. All subjects underwent hybrid positron emission tomography/magnetic resonance imaging. Atlas-based parcellation using a fine-grained Brai

SUBMITTER: Chu M 

PROVIDER: S-EPMC10357174 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature