High-Quality Sleep Mitigates ABCA7-Related Generalization Deficits in Healthy Older African Americans.

ABSTRACT:

Background

Both sleep deficiencies and Alzheimer's disease (AD) disproportionately affect older African Americans. Genetic susceptibility to AD further compounds risk for cognitive decline in this population. Aside from APOE ɛ4, ABCA7 rs115550680 is the strongest genetic locus associated with late-onset AD in African Americans. While sleep and ABCA7 rs115550680 independently influence late-life cognitive outcomes, we know too little about the interplay between these two factors on cognitive function.

Objective

We investigated the interaction between sleep and ABCA7 rs115550680 on hippocampal-dependent cognitive function in older African Americans.

Methods

One-hundred fourteen cognitively healthy older African Americans were genotyped for ABCA7 risk (n = 57 carriers of

SUBMITTER: Sinha N 

PROVIDER: S-EPMC10357211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature