Metabolism of ropinirole is mediated by several canine CYP enzymes.

ABSTRACT:

Background

Ropinirole has been shown to provoke vomiting in dogs by activating the dopamine D2-like receptors in the chemoreceptor trigger zone. In humans, ropinirole is metabolized primarily by CYP1A2. Corresponding dog CYP1A2 is known to be a polymorphic enzyme which can cause variation in pharmacokinetics of compounds metabolised via this enzyme.

Objectives

The aim of this study was to understand metabolic clearance of ropinirole in dogs, the enzymes involved in ropinirole metabolism and specially to estimate whether the clearance can be sensitive towards the polymorphism of canine CYP1A2.

Methods

Metabolism of ropinirole was studied in dog hepatocytes and specific recombinant canine CYP isoforms. Metabolite identification and metabolite formation were evaluated us

SUBMITTER: Tervahauta T 

PROVIDER: S-EPMC10357277 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature