Genetically predicted ankylosing spondylitis is causally associated with psoriasis.

ABSTRACT:

Background

Previous observational studies have reported the striking association between ankylosing spondylitis (AS) and psoriasis, but the causal relationship between the two diseases remains unclear.

Methods

Two-sample Mendelian randomization (MR) analysis with methods of inverse-variance weighted, MR-Egger regression, weighted median, and weighted mode was conducted to evaluate the bidirectional causal associations between AS and psoriasis. Effective single-nucleotide polymorphisms (SNPs) from genome-wide association studies (GWAS) were selected as instrumental variables (IVs). Sensitivity analyses were also applied to verify whether heterogeneity and pleiotropy can bias the results.

Result

We found positive causal effects of genetically increased AS risk on psoria

SUBMITTER: Tian D 

PROVIDER: S-EPMC10357290 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature