An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.

ABSTRACT:

Background

ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription factor containing an N-terminal kinase domain and a C-terminal transcriptional activation domain. Many ERK5 kinase inhibitors have been developed and tested to treat cancer and inflammatory diseases. However, recent data have raised questions about the role of the catalytic activity of ERK5 in proliferation and inflammation. We aimed to investigate how ERK5 reprograms myeloid cells to the proinflammatory senescent phenotype, subsequently leading to atherosclerosis.

Methods

A ERK5 S496A (dephosphorylation mimic) knock in (KI) mouse model was generated using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-assoc

SUBMITTER: Abe JI 

PROVIDER: S-EPMC10357365 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature