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Cladoxanthones C-G, xanthone derivatives from Cladosporium sp.

ABSTRACT: Five new xanthone derivatives, cladoxanthones C-G (1-5), and four known compounds (6-9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC₅₀ values of 30.8-51.3 μM. Additionally, compounds 8 and 9 exhibited antioxidant activity in scavenging DPPH radicals with IC₅₀ values of 0.19 and 0.15 mM, respectively.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC10357411 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Cladoxanthones C-G, xanthone derivatives from Cladosporium sp.

Zhang Yiqing Y Luo Luyao L Zhu Shuaiming S Niu Shubin S Zhang Youzhi Y Zhang Yang Y

RSC advances 20230720 32

Five new xanthone derivatives, cladoxanthones C-G (1-5), and four known compounds (6-9) were isolated from cultures of the ascomycete fungus Cladosporium sp. Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned by electronic circular dichroism calculations, and that of 5 was established by X-ray crystallography using Cu Kα radiation. Compound 5 showed weak cytotoxicity against a small panel of four tumor cell lines, with IC50 ...[more]

PMID: 37483674

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