A novel prognostic signature of chemokines for survival and immune infiltration in kidney renal clear cell carcinoma.

ABSTRACT: Objective: Studies have revealed the alteration of chemokines in the tumour microenvironment in renal clear cell carcinoma (KIRC), which is closely related with immune infiltration and the prognosis of patients with KIRC. This research aims to comprehensively clarify the signature of chemokines in KIRC and the correlation between chemokines and immune infiltration in the TME of KIRC. Methods: The chemokine expression in KIRC were investigated by using multiple multiomics and bioinformatics tools. Hub-chemokines that were significantly related with the cancer stage and survival were identified. The role of hub-chemokines in the tumor microenvironment of KIRC was further assessed by using enrichment analysis, cancer-related pathway and immune infiltration analysis. Results</

SUBMITTER: Weng J 

PROVIDER: S-EPMC10357446 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature