Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.

ABSTRACT: Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer-risk variants from multi-ancestry GWASs and fine-mapping studies (PRS₂₆₉). GW-PRS models were trained with a large and diverse prostate cancer GWAS of 107,247 cases and 127,006 controls that we previously used to develop the multi-ancestry PRS₂₆₉. Resulting models were independently tested in 1,586 cases and 1,047 controls of African ancestry from the California Uganda Study and 8,046 cases and 191,825 controls of European ancestry from the UK Biobank and further validat

SUBMITTER: Darst BF 

PROVIDER: S-EPMC10357473 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature