Oncolytic virus treatment differentially affects the CD56^dim and CD56^bright NK cell subsets in vivo and regulates a spectrum of human NK cell activity.

ABSTRACT: Natural killer (NK) cells protect against intracellular infection and cancer. These properties are exploited in oncolytic virus (OV) therapy, where antiviral responses enhance anti-tumour immunity. We have analysed the mechanism by which reovirus, an oncolytic dsRNA virus, modulates human NK cell activity. Reovirus activates NK cells in a type I interferon (IFN-I) dependent manner, inducing STAT1 and STAT4 signalling in both CD56^dim and CD56^bright NK cell subsets. Gene expression profiling revealed the dominance of IFN-I responses and identified induction of genes associated with NK cell cytotoxicity and cell cycle progression, with distinct responses in the CD56^dim and CD56^bright subsets. However, reovirus treatment inhibited IL-15 induced NK ce

SUBMITTER: Wantoch M 

PROVIDER: S-EPMC10357483 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature