Autoimmune alleles at the major histocompatibility locus modify melanoma susceptibility.

ABSTRACT: Autoimmunity and cancer represent two different aspects of immune dysfunction. Autoimmunity is characterized by breakdowns in immune self-tolerance, while impaired immune surveillance can allow for tumorigenesis. The class I major histocompatibility complex (MHC-I), which displays derivatives of the cellular peptidome for immune surveillance by CD8⁺ T cells, serves as a common genetic link between these conditions. As melanoma-specific CD8⁺ T cells have been shown to target melanocyte-specific peptide antigens more often than melanoma-specific antigens, we investigated whether vitiligo- and psoriasis-predisposing MHC-I alleles conferred a melanoma-protective effect. In individuals with cutaneous melanoma from both The Cancer Genome Atlas (n = 451) and an independent v

SUBMITTER: Talwar JV 

PROVIDER: S-EPMC10357503 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature