Supramolecular Self-Assembly of Engineered Polyproline Helices.

ABSTRACT: The ability to rationally design biomaterials to form desired supramolecular constructs presents an ever-growing research field, with many burgeoning works within recent years providing exciting results; however, there exists a broad expanse of promising avenues of research yet to be investigated. As such we have set out to make use of the polyproline helix as a rigid, tunable, and chiral ligand for the rational design and synthesis of supramolecular constructs. In this investigation, we show how an oligoproline tetramer can be specifically designed and functionalized, allowing predictable tuning of supramolecular interactions, to engineer the formation of supramolecular peptide frameworks with varying properties and, consequently, laying the groundwork for further studies utilizing the po

SUBMITTER: Brightwell DF 

PROVIDER: S-EPMC10357564 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature