Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in COPD. However, bilirubin levels are influenced by multiple intrinsic and extrinsic factors, and these observational studies are prone to confounding. Genetic analyses are one approach to overcoming residual confounding in observational studies.

Objectives

To test associations between a genetic determinant of bilirubin levels and respiratory health outcomes.

Methods

COPDGene participants underwent genotyping at the baseline visit. We confirmed established associations between homozygosity for rs6742078 and higher bilirubin, and between higher bilirubin

SUBMITTER: Baldomero AK 

PROVIDER: S-EPMC10357606 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature