Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children.

ABSTRACT:

Introduction

Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urinary proteome for different spirometry phenotypes in preterm-born children with preterm- and term-born controls.

Methods

Preterm and term-born children aged 7-12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, underwent spirometry and urine collection. Urine was analysed by Nano-LC Mass-Spectrometry with Tandem-Mass Tag labelling. The preterm-born children were classified into phenotypes of prematurity-associated preserved ratio impaired spirometry (pPRISm, FEV₁ < lower limit of normal (LLN), FEV₁/FVC ≥ LLN), prem

SUBMITTER: Course CW 

PROVIDER: S-EPMC10357627 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature