Single-cell RNA sequencing analysis of the temporomandibular joint condyle in 3 and 4-month-old human embryos.

ABSTRACT:

Background

The temporomandibular joint (TMJ) is a complex joint consisting of the condyle, the temporal articular surface, and the articular disc. Functions such as mastication, swallowing and articulation are accomplished by the movements of the TMJ. To date, the TMJ has been studied more extensively, but the types of TMJ cells, their differentiation, and their interrelationship during growth and development are still unclear and the study of the TMJ is limited. The aim of this study was to establish a molecular cellular atlas of the human embryonic temporomandibular joint condyle (TMJC) by single-cell RNA sequencing, which will contribute to understanding and solving clinical problems.

Results

Human embryos at 3 and 4 months of age are an important stage of TMJC developmen

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10357633 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature