Application of genetic risk score for in-stent restenosis of second- and third-generation drug-eluting stents in geriatric patients.

ABSTRACT:

Background

The second-and third-generation drug-eluting stents (DESs) in-stent restenosis (ISR) genetic risk score (GRS) model has been previously validated. However, the model has not been validated in geriatric patients. Therefore, we conducted this study to test the feasibility of the DES-ISR GRS model in geriatric patients with coronary artery disease (CAD) in Taiwan.

Methods

We conducted a retrospective, single-center cohort study and included geriatric patients (age ≥ 65 years) with CAD and second-or third-generation DES(s) deployment. Patients undergoing maintenance dialysis were excluded. ISR was defined as ≥ 50% luminal narrowing on the follow-up coronary arteriography. The DES-ISR GRS model included five selected exonic single-nucleotide polymorphisms (SNPs): CAMLG

SUBMITTER: Hsu YL 

PROVIDER: S-EPMC10357661 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature