Biological activity and structure-activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis.

ABSTRACT: Visceral leishmaniasis is a neglected protozoan disease with high mortality. Existing treatments exhibit a number of limitations, resulting in a significant challenge for public health, especially in developing countries in which the disease is endemic. With a limited pipeline of potential drugs in clinical trials, natural products could offer an attractive source of new pharmaceutical prototypes, not least due to their high chemodiversity. In the present work, a study of anti-L. (L.) infantum potential was carried out for a series of 39 synthetic compounds based on the core scaffold of the neolignan dehydrodieugenol B. Of these, 14 compounds exhibited activity against intracellular amastigotes, with 50% inhibitory concentration (IC₅₀) values between 3.0 and

SUBMITTER: Amaral M 

PROVIDER: S-EPMC10357944 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature