Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces.

ABSTRACT: Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical and therapeutic interventions as well as capturing cellular activity in the intact human brain. A critical component probing human brain activity is the interface material at the electrode contact that electrochemically transduces brain signals to and from free charge carriers in the measurement system. Here, we summarize state-of-the-art electrode array systems in the context of translation for use in recording and stimulating human brain activity. We leverage parametric studies with multiple electrode materials to shed light on the varied levels of suitability to enable high signal-to-noise electrophysiological recordings as well as safe electrophysiological stimulation delivery. W

SUBMITTER: Vatsyayan R 

PROVIDER: S-EPMC10357958 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature