Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?

ABSTRACT: Ovarian cancer has a high mortality rate due, in part, to the lack of early detection and incomplete understanding of the origin of the disease. The hen is the only spontaneous model of ovarian cancer and can therefore aid in the identification and testing of early detection strategies and therapeutics. Our aim was to combine the use of the hen animal model and microarray technology to identify differentially expressed genes in ovarian tissue from normal hens compared with hens with ovarian cancer. We found that the transcripts up-regulated in chicken ovarian tumors were enriched for oviduct-related genes. Quantitative real-time PCR and immunohistochemistry confirmed expression of oviduct-related genes in normal oviduct and in ovaries from hens with early- and late-stage ovarian tumors, bu

SUBMITTER: Trevino LS 

PROVIDER: S-EPMC10358175 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature