Clinical characteristics and prognostic analysis of SMARCA4-deficient non-small cell lung cancer.

ABSTRACT:

Purpose

To improve the understanding of special types of tumors, we summarized and analyzed the clinicopathological features and prognostic factors of SMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC).

Methods

We selected 105 patients with SMARCA4-dNSCLC and 221 patients with SMARCA4-intact non-small cell lung cancer (SMARCA4-iNSCLC) by performing immunohistochemical analysis of 1520 NSCLC samples, and we assessed the patients' clinicopathological features and survival state.

Results

(1) SMARCA4-dNSCLC was significantly associated with older age, male sex, smoking history, larger invasive tumor size, higher tumor proliferation index (Ki-67), more adrenal metastases, more lymph node metastases, and few EGFR mutations (p < 0.05). The tumors were mostly negat

SUBMITTER: Liang X 

PROVIDER: S-EPMC10358186 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature