Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers.

ABSTRACT: Craving reflects the subjective urge to use drugs and can be triggered by both positive and negative emotional states. No studies have systematically investigated the relative roles of these mechanisms in the pathophysiology of substance misuse. Here, we performed meta-analyses of drug cue-elicited reactivity and win and loss processing in the monetary incentive delay task to identify distinct neural correlates of appetitive and aversive responses to drug cues. We then characterized the appetitive and aversive cue responses in seventy-six alcohol drinkers performing a cue craving task during fMRI. Imaging data were processed according to published routines. The appetitive circuit involved medial cortical regions and the ventral striatum, and the aversive circuit involved the insula, caudat

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10358306 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature