Sex difference in the discordance between Abbott Architect and EuroImmun serological assays.

ABSTRACT:

Background

This study evaluated the discordance between Abbott Architect SARS-CoV-2 IgG and EUROIMMUN SARS-COV-2 ELISA in a seroprevalence study.

Methods

From June 10 to August 15, 2020, 8,246 specimens were dually evaluated by the Abbott Architect SARS-CoV-2 IgG (Abbott) and the EUROIMMUN SARS-CoV-2 ELISA (EI) assays. Sex-stratified phi correlation coefficients were calculated to evaluate the concordance between Abbott and EI assay's quantitative results. Multivariable mixed-effect logistic models were implemented to evaluate the association between assay positivity and sex on a low prevalence sample while controlling for age, race, ethnicity, diabetes, cardiovascular disease, hypertension, immunosuppressive therapy, and autoimmune disease.

Results

EI positivity amon

SUBMITTER: Hartsell JD 

PROVIDER: S-EPMC10358334 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature