Maternal protein deficiency alters primary cilia length in renal tubular and impairs kidney development in fetal rat.

ABSTRACT:

Introduction

Intrauterine malnutrition impairs embryo kidney development and leads to kidney disease and hypertension in adulthood, yet the underlying mechanism remains unclear.

Methods

With a maternal protein restriction (MPR) rat model, we investigated the critical ciliogenesis factors and β-catenin pathway in FGR fetal kidneys and analyzed the impact of aberrant primary cilia on renal tubular epithelium.

Results

The data showed decreased nephron number and renal tubular dysgenesis in FGR fetus. FGR fetus showed deregulated expression of ciliogenesis factors including upregulation of IFT88 and downregulation of DYNLT1, accompanied with cilia elongation in renal tubular epithelial cells. Wnt7b, the key ligand for Wnt/β-catenin signaling, was downregulated and nuclear

SUBMITTER: Wang J 

PROVIDER: S-EPMC10358357 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature