The association of aldosterone and endothelin-1 with incident diabetes among African Americans: The Jackson Heart Study.

ABSTRACT:

Introduction

African Americans (AAs) have the highest prevalence of hypertension among United States racial/ethnic groups. Regulators of blood pressure, such as aldosterone and endothelin-1, impact glucose regulation. The relationship between these factors and incident diabetes is not well elucidated among AAs.

Methods

Among 3914 AA participants without prevalent diabetes in the Jackson Heart Study, linear regression models were used to examine cross-sectional associations of exposures (aldosterone, endothelin-1, and a combined aldosterone-endothelin-1 score [2-8]) with glycemic measures (fasting plasma glucose [FPG], HbA1c, homeostatic model assessments of beta cell function [HOMA-β] and insulin resistance [HOMA-IR]). Longitudinal associations of exposures with incident dia

SUBMITTER: Joseph JJ 

PROVIDER: S-EPMC10358435 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature