Elevated PaCO₂ levels increase pulmonary artery pressure.

ABSTRACT: Permissive hypercapnia is commonly used in mechanically ventilated patients to avoid lung injury but its effect on pulmonary artery pressure (PAP) is still unclear, particularly in combination with tidal volume (Vt). Therefore, an in vivo study was performed on adult rabbits ventilated with low (9 ml/Kg, LVt group) or high (15 ml/Kg, HVt group) tidal volume (Vt) and alterations in PAP were estimated. Both groups of animals initially were ventilated with FiO₂ 0.3 (Normocapnia-1) followed by inhalation of enriched CO₂ gas mixture (FiCO₂ 0.10) to develop hypercapnia (Hypercapnia-1). After 30 min of hypercapnia, animals were re-ventilated with FiO₂ 0.3 to develop normocapnia (Normocapnia-2) again and then with FiCO₂ 0.10 to develop

SUBMITTER: Triantaris A 

PROVIDER: S-EPMC10358613 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature