Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series.

ABSTRACT: A lung abscess is a necrotizing infection caused by microbiomes that lead to the loss of healthy lung tissue. The routine culture is a waste of time and yields false-negative results, and clinicians could only choose empiric therapy or use broad-spectrum antibiotics, which could significantly contribute to the problem of resistance or aggravate the condition. We report three patients with a routine-culture-negative lung abscess. The presenting symptoms included fever, cough, dyspnea, and chest pain, and a computed tomography scan revealed a lesion in the lungs. The bronchoalveolar lavage fluid and pleural fluid were tested for pathogens using metagenome next-generation sequencing (mNGS), and the results revealed Fusobacterium nucleatum and Streptococcus spp. (S. constellat

SUBMITTER: Wang N 

PROVIDER: S-EPMC10358748 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature