SARS-CoV-2 protein structure and sequence mutations: Evolutionary analysis and effects on virus variants.

ABSTRACT: The structure and sequence of proteins strongly influence their biological functions. New models and algorithms can help researchers in understanding how the evolution of sequences and structures is related to changes in functions. Recently, studies of SARS-CoV-2 Spike (S) protein structures have been performed to predict binding receptors and infection activity in COVID-19, hence the scientific interest in the effects of virus mutations due to sequence, structure and vaccination arises. However, there is the need for models and tools to study the links between the evolution of S protein sequence, structure and functions, and virus transmissibility and the effects of vaccination. As studies on S protein have been generated a large amount of relevant information, we propose in this work to

SUBMITTER: Lomoio U 

PROVIDER: S-EPMC10358949 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature