A computational modeling framework for pre-clinical evaluation of cardiac mapping systems.

ABSTRACT: There are a variety of difficulties in evaluating clinical cardiac mapping systems, most notably the inability to record the transmembrane potential throughout the entire heart during patient procedures which prevents the comparison to a relevant "gold standard". Cardiac mapping systems are comprised of hardware and software elements including sophisticated mathematical algorithms, both of which continue to undergo rapid innovation. The purpose of this study is to develop a computational modeling framework to evaluate the performance of cardiac mapping systems. The framework enables rigorous evaluation of a mapping system's ability to localize and characterize (i.e., focal or reentrant) arrhythmogenic sources in the heart. The main component of our tool is a library of computer simulations

SUBMITTER: Galappaththige S 

PROVIDER: S-EPMC10358980 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature