The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.

ABSTRACT: The perforant path provides the primary cortical excitatory input to the hippocampus. Because of its important role in information processing and coding, entorhinal projections to the dentate gyrus have been studied in considerable detail. Nevertheless, synaptic transmission between individual connected pairs of entorhinal stellate cells and dentate granule cells remains to be characterized. Here, we have used mouse organotypic entorhino-hippocampal tissue cultures of either sex, in which the entorhinal cortex (EC) to dentate granule cell (GC; EC-GC) projection is present, and EC-GC pairs can be studied using whole-cell patch-clamp recordings. By using cultures of wild-type mice, the properties of EC-GC synapses formed by afferents from the lateral and medial entorhinal cortex were compare

SUBMITTER: Lenz M 

PROVIDER: S-EPMC10359033 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature