E-value: a superior alternative to P-value and its adjustments in DNA methylation studies.

ABSTRACT: DNA methylation plays a crucial role in transcriptional regulation. Reduced representation bisulfite sequencing (RRBS) is a technique of increasing use for analyzing genome-wide methylation profiles. Many computational tools such as Metilene, MethylKit, BiSeq and DMRfinder have been developed to use RRBS data for the detection of the differentially methylated regions (DMRs) potentially involved in epigenetic regulations of gene expression. For DMR detection tools, as for countless other medical applications, P-values and their adjustments are among the most standard reporting statistics used to assess the statistical significance of biological findings. However, P-values are coming under increasing criticism relating to their questionable accuracy and relatively high levels of false positi

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10359086 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature