Microstructure characterization of a decellularized vocal fold scaffold for laryngeal tissue engineering.

ABSTRACT:

Objectives/hypothesis

One potential treatment for vocal fold injury or neoplasia is to replace the entire vocal fold with a tissue-engineered scaffold. This scaffold should ideally have similar mechanical properties and extracellular matrix composition as the native vocal fold. As one approach toward this goal, we decellularized human vocal folds and characterized their mechanical properties and extracellular matrix microstructure.

Study design

Basic science investigation.

Methods

Human vocal folds were dissected from the laryngeal framework and treated with sodium dodecyl sulfate (SDS) to remove all cells. Mechanical properties were measured by indentation before and after SDS treatment. The extracellular matrix components of collagen, laminin, elastin, and hyaluroni

SUBMITTER: Tse JR 

PROVIDER: S-EPMC10359100 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature