Eye-brain axis in microgravity and its implications for Spaceflight Associated Neuro-ocular Syndrome.

ABSTRACT: Long-duration human spaceflight can lead to changes in both the eye and the brain, which have been referred to as Spaceflight Associated Neuro-ocular Syndrome (SANS). These changes may manifest as a constellation of symptoms, which can include optic disc edema, optic nerve sheath distension, choroidal folds, globe flattening, hyperopic shift, and cotton wool spots. Although the underpinning mechanisms for SANS are not yet known, contributors may include intracranial interstitial fluid accumulation following microgravity induced headward fluid shift. Development and validation of SANS countermeasures contribute to our understanding of etiology and accelerate new technology including exercise modalities, Lower Body Negative Pressure suits, venous thigh cuffs, and Impedance Threshold Devices.

SUBMITTER: Stern C 

PROVIDER: S-EPMC10359255 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature