Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications.

ABSTRACT: Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index-BMI ≥ 30 kg/m²; n = 36) and non-obese (BMI < 30 kg/m²; n = 36). The lipidomic profiles were evaluated in plasma using ¹H nuclear magnetic resonance (¹H-NMR) spectroscopy. Obese individuals had higher waist circumference (p < 0.001), visceral adiposity index (p = 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p = 0.010), and triacylglycerols (TAG) levels (p = 0.018). ¹H-NM

SUBMITTER: Bellot PENR 

PROVIDER: S-EPMC10359283 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature