Identifying healthy individuals with Alzheimer's disease neuroimaging phenotypes in the UK Biobank.

ABSTRACT:

Background

Identifying prediagnostic neurodegenerative disease is a critical issue in neurodegenerative disease research, and Alzheimer's disease (AD) in particular, to identify populations suitable for preventive and early disease-modifying trials. Evidence from genetic and other studies suggests the neurodegeneration of Alzheimer's disease measured by brain atrophy starts many years before diagnosis, but it is unclear whether these changes can be used to reliably detect prediagnostic sporadic disease.

Methods

We trained a Bayesian machine learning neural network model to generate a neuroimaging phenotype and AD score representing the probability of AD using structural MRI data in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Cohort (cut-off 0.5, AUC 0.92, PPV 0.90

SUBMITTER: Azevedo T 

PROVIDER: S-EPMC10359360 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature