How and what adverse events are reported and captured in randomized control trials of emollients in the treatment of eczema?

ABSTRACT:

Background

Emollients are universally recommended for atopic dermatitis/eczema ('eczema'), to improve the skin barrier and reduce symptoms. However, our knowledge of the frequency and nature of adverse effects associated with their use is limited.

Objectives

We sought to determine how well adverse events are reported in randomized controlled trials (RCTs) of emollients for eczema.

Methods

MEDLINE was searched from inception (1946) to May 2022. Inclusion criteria were RCTs of moisturizers or emollients used as a leave-on treatment (as the intervention or control) in adults or children with eczema. Exclusion criteria were non-RCTs; patients with other diagnoses included; use of emollient as bath additives, soap substitutes or as preventative; and not published in Englis

SUBMITTER: Emmett ER 

PROVIDER: S-EPMC10359396 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature